Journal: CNS Neuroscience & Therapeutics

Article Title: Hydrogen Sulfide Modulates Microglial Polarization and Remodels the Injury Microenvironment to Promote Functional Recovery After Spinal Cord Injury

doi: 10.1111/cns.70431

Figure Lengend Snippet: H 2 S improves motor function in mice after SCI. (A) Schematic representation of the experimental design. (B) BMS scores of mice at the indicated times post‐SCI. (C) Example stick diagrams of hindlimb movements in the sham, vehicle, and 20 mg/kg ADT groups. (D) Ankle angle degree curves in the sham, vehicle, and 20 mg/kg ADT groups. (E) Quantification of ankle angles in the sham, vehicle and 20 mg/kg ADT groups. (F) EMGs of the TA muscles in the sham, vehicle, and 20 mg/kg ADT groups. (G) Quantification of the average duration of a single TA burst in EMG in the sham, vehicle and 20 mg/kg ADT groups. (H) Quantification of the maximum amplitude of EMG bursts in the sham, vehicle and 20 mg/kg ADT groups. Data are presented as mean ± SEM; n = 10 per group (B); n = 5 per group (E, G, H). Statistical analyses were performed using one‐way ANOVA, followed by Tukey's post hoc test (E, G, H) or two‐way ANOVA, followed by Bonferroni's post hoc test for multiple comparisons (B). * p < 0.05, ** p < 0.01, *** p < 0.001, and ns indicates no statistically significant difference.

Article Snippet: A recording electrode was implanted in the tibialis anterior (TA) muscle of the right hindlimb and connected to an EMG recording module (BIOPAC, USA) via the Biopac MP150 data acquisition system [ ].

Techniques: Muscles